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www.bushiboke.orgContact UsHuman Chorionic Gonadotropin – a Versatile ToolPosted on April 7, 2015by Charles GrahamThe egg is fertilized in the fallopian tube by the sperm. In a period of 9 days, the fertilized egg will travel down to the uterus and affix itself to the uterine wall. This process is known as implantation. After implantation, the placenta will begin to develop and start to release a hormone known as the human chorionic gonadotrophin (HCG) into your blood. Some of these hormones are passed in your urine.The HCG levels in the blood and urine is used to determine pregnancy and germ cell tumors that can be an indication of either molar pregnancy or cancer in the uterus. In men, HCG levels are used to determine possible cancer of the testicles.HCG in WomenFor women, the presence of HCG is necessary for healthy pregnancy. It bolsters the maintenance of corpus luteum, a temporary endocrine structure, during the start of pregnancy. The corpus luteum secretes progesterone, a steroid hormone, throughout the first trimester. Progesterone supplements the uterus with a thick lining of capillaries and blood vessels (endometrium) so it can maintain the growing fetus.During the first trimester, the HCG hormone repels the immune cells of the mother, keeping the fetus protected. It is also believed that HCG may be a placental link for local maternal immunotolerance development. An increase in the death of T cells is induced in HCG-treated endometrial cells. This suggests that HCG could be correlated to peritrophoblastic immune tolerance development and that it may aid the trophoblast invasion, which assists in the progress of the fetus’ development in the endometrium.This hormone is also believed to affect the severity of morning sickness in women who are pregnant. Since HCG has great similarities to LH (luteinizing hormone), it is used to induce ovulation in the female ovaries and to promote the production of testosterone in the testes.In relation to fertility treatment, some organizations collect urine from pregnant women to extract HCG. This is because pregnant women are the most abundant source of biological HCG. Fertility treatments, such as Choragon, Follutein, Novarel, Pregnyl and Profasi, are extracted from pregnant women’s urine. Ovidrel, on the other hand, is produced using recombinant DNA technology.HCG for Cancer DiagnosisHuman Chorionic Gonadotropin is also used as a tumor marker. This is because the β subunit of this hormone is also released by certain kinds of cancers such as: germ cell tumors, choriocarcinoma, hydatidiform mole formation, seminoma, islet cell tumor, and teratoma. This is why a positive HCG result in male patients means testicular cancer is a possible diagnosis. Used in combination with alpha-fetoprotein, β-HCG is an excellent tool for monitoring germ cell tumors.Side EffectsThere are no significant side effects reported with the use of HCG treatments. Still, it’s crucial to remember that each individual has different
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