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The Newest FashionShow you the world fashionRss Feed搜索:Custom SearchAn investigation of the antimicrobial and anti-inflammatory activities of crocodile oil一月 11th, 2013 . No Comments »Crocodile oil has been used by traditional practitioners world-wide to treatmicrobial infections and inflammatory conditions.However, the scientific rationale behind its use is not completely understood.This study provides an updated fatty acid profile and novel scientific evidenceof the antimicrobial and anti-inflammatory properties of crocodile oil, obtained from the Nile crocodile (Crocodylus niloticus), justifying its use by traditional healers.Materials and methods: The fatty acid content of the oil was determined by gas chromatography and the major fatty acids were identified.A microplate method was used to assess activity of the oil against Staphylococcus aureus,Klebsiella pneumoniae and Candida albicans.The anti-inflammatory activity of the oil was assessed by oral administration and topical application,utilising a mouse model of acute croton oil-induced contact dermatitis.Results: Sixteen fatty acids were identified with oleic, palmitic and linoleic acidbeing the major components of the oil.The optimal activity of the oil against the bacteria and fungus was obtained with 15% and 6% (w/v) oil respectively.No significant selectivity was observed against the bacterial species, but Candida albicanswas more susceptible.The anti-inflammatory assays showed optimal activity at 3 h after the oral administration of oil (60.8±5.5%)and at 12 h after topical application (57.5±5.9%).This suggested a short duration of action when the oil was orally administered, and a longer durationof action when it was topically applied.Conclusions: Subsequent studies may be directed towards the investigation of the mechanisms of action of the antimicrobialand anti-inflammatory activities of crocodile oil and its fatty acids.Fig. 1. Microbial susceptibility to oil obtained from the Nile crocodile, Crocodylus niloticus.The percentage growth of Staphylococcus aureus (A), Klebsiella pneumoniae (B) and Candida albicans (C) was measured against increasing concentrations oil (% v/v).Data are the mean±standard error of the mean of duplicate measurements from 7–9 independent experiments.Statistical comparisons of activity were by one-way ANOVA followed by Bonferroni’s post-test; ***, P<0.001 versus no oil control.Fig. 2. The oral anti-inflammatory activity of oil obtained from the Nile crocodile, Crocodylus niloticus.Activity was measured in a mouse model of acute contact dermatitis.Indomethacin (2 mg/100 μl) and crocodile oil (200 μl) was orally administered and the mice treated for 3, 6 or 12 h.After treatment, the reduction in swelling of the auricular biopsies was determinedand the change in weight was expressed as a percentage.Data is the mean±standard error of the mean of duplicate measurements from at least 4 independent experiments.Statistical comparisons of activity were
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