Butte Lab–SearchThis Site OnlyStanford Medical SitesWays to GiveFind a PersonAlumniLane LibraryWays to GiveFind a PersonButte LabOur lab aims to address fundamental and therapeutic questions in immunology by developing and using tools from soft lithography and advanced microscopy to visualize and manipulate cells. The primary focus is on understanding the molecular controls that balance T cell activation versus tolerance. The ultimate aim of our laboratory is to manipulate T cell signaling pathways to control immunologically-mediated diseases. We are also developing low-cost diagnostic technologies for screening of immune-deficiencies and for autoimmunity.Technologies our lab uses include:Live-cell microscopyBiological atomic force microscopy (AFM)Single-molecule manipulationMicrofluidics & soft lithographyLasers and opticsWe welcome PhD students from Bioengineering, Mechanical Engineering, Materials Science & Engineering, Biophysics, Immunology, Physics, or Applied Physics to come visit the lab.Dr. Butte sees patients in the  Immunodeficiency Clinic at Lucile Packard Children's Hospital.NewsAug '13 The lab is awarded an NSF grant for 3 years for mechanobiologyJuly '13 Andrew's collaborative work with Vahid Serpooshan in Pilar Ruiz-Lozano's lab is accepted for publichation in BiomaterialsJune '13 Manish is awarded the Tashia and John Morgridge Faculty Scholar award by the Stanford Child Health Research Institute5/26/13 Our collaborative paper is published in Acta Biomaterialia developing microneedles for diagnosting food allergies, perfomed with the Stanford BioADD team i2/19/13 Marc's paper on GPU-accelerated 3D deconvolution was published in Optics Express.1/7/13 Welcome to PhD rotation students Kenneth Hu (Biophysics) and Nick Bayless (Immunology)10/9/12 Jianwei's technique for labeling a single molecule on the AFM tip is accepted for publication in Applied Physics Letters10/1/12 Welcome to our two new PhD rotation students, Adi de la Zerda (MatSci & Eng) and Thomas Keller (Immunology)               5/18/12 Jianwei publishes a string of papers in using AFM to measure cardiomyocytes, in Science Translational Medicine, in PLoS ONE, in Stem Cells and Development, and again in PLoS ONE. 4/24/12 Tim wins a slot on the T32 -- Training Grant in Adult and Pediatric Immunology. Congrats!3/7/12 Our second paper, on the use of our planar waveguides for counting cells, is published in Biomicrofluidics. Press release here. Manish was interviewed this morning on KGO/ABC news radio!3/5/12 Welcome Tim Thauland, our newest postdoc, who completed his PhD in the Parker Lab at OHSU.1/23/12 Our first paper is published on waveguide-diagnostics technology in Applied Physics Letters.1/16/12 Welcome Dara Strauss-Albee and Sarah Denny, PhD rotation students12/2011 Manish wins Stanford Immunology Outstanding Faculty Mentor award8/2011 Congratulations to Dan for finishing his postdoc and starting med school at Columbia Univ.5/2011 Manish gives LPCH Grand Rouds