avastin.org
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Glossary on off Prescribing Information | Información En Español - AAA + print page e-mail page link to this page To: Enter a valid recipient name To: Enter a valid recipient email address From: Enter a valid name From: Enter a valid email address Message Enter a valid message X Send Colorectal Cancer Lung Cancer Glioblastoma Kidney Cancer Are you a Healthcare Provider? Avastin Support Line 24/7 access to Oncology Nurses1-877-4AVASTIN Click here Coverage and Reimbursement Click here How Avastin is Designed to Work Click here Hear from Real Patients Click here Download Free Educational Materials Click here Indication Metastatic Colorectal Cancer (mCRC) Avastin, when started with the first or second intravenous 5-FU–based chemotherapy for a patient's metastatic cancer, is approved to treat metastatic colorectal cancer (mCRC). Non–Small Cell Lung Cancer (NSCLC) Avastin, in combination with carboplatin and paclitaxel, is approved to treat advanced nonsquamous non–small cell lung cancer (NSCLC) in people who have not yet received chemotherapy for their advanced disease. Glioblastoma (GBM) Avastin is approved to treat glioblastoma (GBM) in adult patients whose cancer has progressed after prior treatment. The effectiveness of Avastin in GBM is based on tumor response. Currently, no data have shown whether or not Avastin improves disease-related symptoms or survival in people previously treated for GBM. Metastatic Kidney Cancer (mRCC) Avastin, used with interferon alfa, is approved to treat metastatic kidney cancer. Possible Serious Side Effects and Additional Important Safety Information What is the most serious safety information I should know about Avastin? Avastin can result in a serious, and sometimes fatal, side effect called gastrointestinal (GI) perforation. GI perforation is the development of a hole in the stomach, small intestine, or large intestine. Symptoms may include abdominal pain, nausea, vomiting, constipation, and fever. Avastin therapy should be stopped if GI perforation occurs. Treatment with Avastin can lead to slow or incomplete wound healing (for example, when a surgical incision has trouble healing or staying closed). In some cases, this event resulted in fatality. Stop Avastin for at least 28 days before voluntary surgery. Do not start Avastin for at least 28 days after surgery and until the surgical wound is fully healed. Avastin therapy should be stopped in patients who experience slow or incomplete wound healing. Treatment with Avastin can result in serious and sometimes fatal bleeding. This includes coughing up blood, bleeding in the stomach, vomiting blood, bleeding in the brain, nosebleeds, and vaginal bleeding. People who have recently coughed up blood or have serious bleeding should not receive Avastin. What are the additional possible seriou
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